Myocardial hypertrophy reduces transmural variation in mitochondrial function
نویسندگان
چکیده
منابع مشابه
Myocardial hypertrophy reduces transmural variation in mitochondrial function
There is growing evidence that some cellular properties of mammalian hearts are transmurally heterogeneous, varying systematically from the inner (sub-endocardium) to the outer (subepicardium) region of the left ventricular wall. For example, action potential duration (Lou et al., 2011), calcium sensitivity (Cazorla et al., 2005; Haynes et al., 2014), mitochondria with faster sedimentation rate...
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OBJECTIVE Increased mechanical stress and contractility characterizes normal left ventricular (LV) subendocardium (Endo) but whether Endo mitochondrial respiratory chain complex activities is reduced as compared to subepicardium (Epi) and whether pressure overload-induced LV hypertrophy (LVH) might modulate transmural gradients through increased reactive oxygen species (ROS) production is unkno...
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ژورنال
عنوان ژورنال: Frontiers in Physiology
سال: 2014
ISSN: 1664-042X
DOI: 10.3389/fphys.2014.00178